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Title: Applications of ionic liquids to oligosaccharide synthesis
Author: Whitaker, Simon Richard
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2013
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The synthesis of a library of biologically relevant oligosaccharide fragments is proposed using ionic liquids as purification tags. Work to synthesise ,B(1-t3)-glucans as a model using this functionality has been considered and synthesis of a range of orthogonally protected glycosyl donors and glycosyl acceptors with ionic liquid purification tags has been achieved. Glycosylations using these building blocks resulting in ionically-tagged oligosaccharides have been performed and the results analysed herein. A continuation of previously published work using ionic liquids as mild room temperature glycosylation promoters is also reported: A variety of glycosyl donors were synthesised and tested with ionic liquids to determine reactivities of donors compatible with this methodology. Proposals to further the scope of this synthetic technique are also discussed.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available