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Title: The effect of acute and chronic cocaine on fast network oscillations in the rat prefrontal cortex in vitro
Author: O'Donovan, Bernadette
Awarding Body: University of Newcastle Upon Tyne
Current Institution: University of Newcastle upon Tyne
Date of Award: 2012
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Chronic exposure to cocaine can result in long-term neuroadaptations in various brain regions including the medial prefrontal cortex (mPFC). Fast network activity in the beta (13-30 Hz) and gamma (3D-80Hz) frequency ranges have been implicated in memory processes and alterations in oscillatory activity have been reported in cocaine addicts. While behavioural and cellular adaptations due to cocaine exposure have been widely investigated, the effects of cocaine on network oscillations in vitro have yet to be demonstrated. Fast network oscillations were established in the anterior cingulate (AC) and infralimbic (IL) regions of the mPFC by application of carbachol and kainate. The effects of acute cocaine on fast network oscillations in the AC and IL were assessed in drug naive rats, sub-chronic cocaine treated rats, and cocaine self-administering rats. In drug naive rats fast network oscillations in the AC were reduced by acute cocaine application, while oscillations in the IL were not affected. The different effects of acute psychostimulants in the AC and IL may be due to more endogenous release of NA and DA in the AC than the IL. Sub-chronic treatment with cocaine followed by 3 or 10 days withdrawal did not alter the generation of fast network oscillations in the AC or IL, or the response to acute cocaine application. Cocaine SA followed by 2 weeks withdrawal altered the effects of acute cocaine and amphetamine on fast network oscillations in the AC and IL. In the IL fast network oscillations were suppressed by acute cocaine and amphetamine. In the AC oscillations were not affected by acute cocaine or amphetamine. This indicates cocaine SA and withdrawal causes neuroadaptations in the mPFC, which may represent adaptations to the learning and memory processes and response to cocaine.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available