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Title: Studies related to synthesis of tetracycline
Author: Clive, Derrick Lawrence Joel
Awarding Body: University of London
Current Institution: Imperial College London
Date of Award: 1966
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This thesis describes three aspects of tetracycline chemistry: 1. Reactions of the tetracyclines and their derivatives. 2. Published achievements in the field of tetracycline synthesis. 3. Advances made by chemists of this laboratory towards total synthesis of a natural tetracycline. The author's work on this project involved: a. An examination of the suitability of metal-ammonia solutions for reduction of the amides A and B to the corresponding dihydro-compounds C and D. Only the simpler dihydro-amide C could be obtained. b. An unsuccessful search for methods of inserting nitrogen into the double bond of an enol ether. During this work a new type of hydroxylamine derivative E was synthesised and its reactions were studied.
Supervisor: Barton, D, H. R. Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available