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Title: Structure and biosynthesis in melanin
Author: Ogunkoya, Layi
Awarding Body: University of London
Current Institution: Imperial College London
Date of Award: 1965
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The problems of melanin biogenesis and structure are reviewed up to date. Preparative procedures are outlined for the labelling of phenols with deuterium and tritium by exchange in alkaline and in acidic solutions. The use of phenols, labelled with tritium at the ortho and Para positions, in biosynthetic investigations is discussed. The methods developed are illustrated by the synthesis of (+)-31 4-dihydroxyphenylalanine (dopa) labelled specifically with tritium at each of its nuclear positions; and also at its side chain positions. Tracer studies with variously labelled dopas have shown that the melanin pigment is quite irregular in structure and that regular structures hitherto postulated cannot be correct. A radio dilution study has shown that pyrrole2,3-dicarboxylic acid is produced in very small amount from the oxidative degradation of melanin.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available