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Title: The mechanism of Nov (CCN3) function in haematopoiesis
Author: Guo, Yanping
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 2012
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Haematopoietic stem cells (HSC) are strictly regulated by intrinsic regulators and extrinsic signals from the microenvironment. Nov (CCN3), a matricellular protein of the CCN family, has been reported as a suppressor gene in solid tumours and chronic myeloid leukaemia (CML). Recent study identified Nov as a positive regulator in human cord blood CD34+ stem cells. However, the functions of Nov in haematopoiesis and adult HSC remain largely unknown.
Supervisor: Enver, Tariq ; Vyas, Paresh Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Cell Biology (see also Plant sciences) ; Blood ; Stem cells (clinical sciences) ; Haematology ; Haematopoiesis ; Haematopoietic stem cells ; Nov(Ccn3)