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Title: Antimicrobial effects of white tea extracts in combination with putative adjuncts against 'Staphylococcus aureus' and other microbes of importance
Author: Holloway, Andrew Charles
Awarding Body: Kingston University
Current Institution: Kingston University
Date of Award: 2013
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Previous studies have investigated biological activities of plant extracts and their subcomponent compounds as antimicrobial treatments. The addition of adjunct substances in varying combinations to such agents has also been shown to enhance their antimicrobial activities - a desirable outcome in the development of novel treatment substances to combat pathogens. Whole extracts of tea leaves processed in different ways to produce black, green and white tea types (BT, GT, WT) show different activities. In addition, the effects on pathogens of highly active GT extract rich in flavan-3-ols which are catechins have also been investigated alone and with additives and these can compare favourably with the activities of conventional antibiotics such as oxacillin and ciprofloxacin. However, relatively little attention has been paid to enhancing the activity of whole WT or its weak antimicrobial subcomponents. The activities of GT and BT were compared to the less researched white tea (WT). Principal tea flavan-3-ols were also screened for activity alone, and combined with a known antimicrobial agent copper(II)sulphate against 'Staphylococcus aureus' NCTC 06751. WT, a sub-fraction, (WTF
Supervisor: Gould, Simon ; Fielder, Mark ; Naughton, Declan ; Harvey, Irene Mueller ; Kelly, Alison Sponsor: Kingston University
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Biological sciences