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Title: Silicon in synthesis : β-silylated carbonyl compounds and O-silylated dienolates
Author: Goldhill, Jonathan Paul
Awarding Body: University of Cambridge
Current Institution: University of Cambridge
Date of Award: 1979
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The synthesis of β-silylated carbonyl compounds and their use as masked αβ-unsaturated carbonyl compounds is described. The β-silylated function in these molecules is stable to most reaction conditions, yet the introduction of a leaving group in the α-position and reaction with a suitable nucleophile for silicon gives an α-methylene carbonyl. The reactions of O-silylated dienolates with a range of electrophiles were investigated and shown to provide a partial solution to the problem of the γ-alkylation of αβ-unsaturated carbonyl compounds.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available