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Title: Investigation into the mechanism of RNA polymerase I inhibition by the anticancer agent 9-hydroxyellipticine
Author: Andrews , William John
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2013
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Transcription by RNA polymerase 1 (Pol-1) is the main driving force behind ribosome biogensis, a fundamental cellular process that requires the coordinated transcription of all three nuclear polymerases. Increased Pol-1 transcription, and the concurrent increase in ribosome biogensis has been linked to the high rates of proliferation in many cancers. The ellipticine family contains a number of potent anticancer therapeutic agents with some having progressed to stage 1 and II clinical trial; however the mechanism by which these compounds works remain unclear.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available