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Title: Surface modification of polyetheretherketone (PEEK) for implant applications
Author: Corfield, V. I.
Awarding Body: University of Cambridge
Current Institution: University of Cambridge
Date of Award: 2005
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Topographical modification of polymers can be utilised to control the cellular interaction without the underlying bulk material. In this study, polyetheretherketone (PEEK), a polymer used in clinical applications and a possible replacement to ultra high molecular weight polyethylene (UHMWPE), has been topographically modified using laser ablation and heat embossing. Topographical and chemical characterisations of the surfaces were performed. The subsequent osteoblast-like cell response was measured using human osteosarcomas SaoS-2 and MG63 cell lines and the non-transformed MC3T3-E1 cell line established from newborn mouse calvaria. Cell attachment, spreading, proliferation and differentiation were investigated on the different polymer surfaces. Laser ablation was performed using projection imaging and contact masking techniques. The groove-ridge topography affected the osteoblast-like cell response. Although cell proliferation and differentiation were not altered, the relative cell attachment to the grooves and ridges was affected by the surface modification technique and the groove width, whereas the groove depth did not have an effect. It is likely that both topographical and chemical modifications produced during laser ablation affect the cell attachment, although separation of the individual effects is not possible. The groove-ridge dimensions also affected the individual cell response. Cell alignment resulted within shallow narrow grooves, including the surface diffraction patterns, whilst cells tended to bridge the deeper narrow grooves and follow the contours of wider grooves. This study has shown that both laser ablation and heat embossing can be used to produce topographical modifications on PEEK surfaces, which subsequently alter the osteoblast-like cell response. While there is only a small difference in the biological response, it is suggested that heat embossing would be the preferred surface modification technique for a medical implant.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available