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Title: Callipeltosides A-C : a synthetic study
Author: Booth, R. A.
Awarding Body: University of Cambridge
Current Institution: University of Cambridge
Date of Award: 2010
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This thesis describes work toward the total synthesis of callipeltosides A-C, a group of structurally related and intriguing glycosidic macrolides isolated from the marine sponge Callipelta sp., which exhibit marked cytotoxic activity. Part A describes the total syntheses of the sugar moieties of callipeltoside A and callipeltoside C, which rely purely on substrate control and are the shortest syntheses to date. Part B describes the synthesis of the C10-C22 fragment via a challenging olefination coupling reaction to form the C16-C17 alkene and subsequent studies towards its union with the C1-C9 pyran fragment.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available