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Title: Motor pathway control of cerebellar climbing fibres
Author: Baker, M. R.
Awarding Body: University of Cambridge
Current Institution: University of Cambridge
Date of Award: 2000
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An electrophysiological approach has been employed to achieve a clearer understanding of the descending projections to the mammalian cerebellar climbing fibre (CF) system and of their integration with cutaneous afferent (CUT) information also arriving within the CF system. 1. Throughout the intermediate zone of the cerebellum of both the rat and the ferret CF responses (CFRs) could be evoked from both the medullary pyramid (PT) and CUT. In both species, the axons within the PT that evoked CFRs conduct at approximately a tenth of the velocity of the fastest corticofugal axons and CFRs could be evoked at the level of the cervico-medullary junction. In addition, in the ferret, CFRs could be evoked in the same zones of the cerebellum by stimulating in the region of the parvocellular red nucleus (RN). In the ferret, synaptic input from CST, RN and CUT converges onto single rostral dorsal accessory olive (rDAO) neurones, the origin of these CFs. 2. When the refractoriness of CF single units was explored by delivering test stimuli to heteronymous synaptic inputs, at different time intervals, there was a 10-20% probability of observing responses to both stimuli at intervals of 30-40 ms suggesting that the refractoriness of rDAO neurones, as described previously (approximately 100 ms) by testing homonymous synaptic inputs, is overestimated. 3. Field potential oscillations, in the 8-12 Hz range, recorded from the rDAO of the ferret, and assumed to be representative of the synchronous potential change of individual neurones, influenced the probability of evoking responses from the CST or RN but not from sensory afferents.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available