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Title: Molecular host response to influenza virus infections in primary pig and human cells
Author: Nelli, Rahul Kumar
Awarding Body: University of Nottingham
Current Institution: University of Nottingham
Date of Award: 2013
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Conventional swine and human influenza viruses are usually not life threatening in their respective host. However the outcomes of highly pathogenic avian influenza (HPAI) H5Nl infections in humans (-60% mortality, WHO, 2011) and pigs (mild or absent; Nidom, 2010) are in sharp contrast. To investigate the biological basis of resistance in pigs to highly pathogenic avian H5Nl infections, we examined the host receptor distribution for virus binding, which could provide valuable comparative information of virus affinity between pigs and humans. A major determinant of influenza infection is the presence of virus receptors on susceptible host cells to which the viral haemagglutinin is able to bind. Avian viruses preferentially bind to sialic acid 0.2, 3-galactose (SAa2, 3- Gal) linked receptors, whereas human strains bind to sialic acid a2, 6-galactose (SAa2, 6-Gal) linked receptors. The relative expression and spati al distribution of SAa2, 3-Gal and SAa2, 6-Gal receptors in the major organs of pigs were examined, by lectin histochemistry.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available