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Title: FBXW7 (hCDC4) E3-ubiquitin ligase receptor : lineage potential and its commitment to cancer
Author: Li, Ningning
Awarding Body: University of Nottingham
Current Institution: University of Nottingham
Date of Award: 2012
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The crucial decision between stem cell self-renewal and differentiation must be tightly controlled, as it could otherwise contribute to tumorigenesis from expanding number of immortal, proliferative, partially differentiated cells. Despite the well-established links between signalling and transcriptional activity in relation to the regulatory mechanisms surrounding stem cell biology and tumorigenesis, little is known about how transcriptional activators/regulators are regulated after tumorigenesis is triggered. An obvious mechanism limiting the expression time of an activator is to destruct it via the ubiquitin-proteasome system (UPS).
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available