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Title: The effect of insulin-induced hypoglycaemia on myocardial blood flow reserve in patients with Type 1 Diabetes and healthy humans : a study using myocardial contrast echocardiography
Author: Rana, Omar
Awarding Body: University of Southampton
Current Institution: University of Southampton
Date of Award: 2011
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Background: Hypoglycaemia is associated with increased cardiovascular mortality (CVM) but the reason for this is poorly understood. We tested the hypothesis that the myocardial blood flow reserve (MFBR) is decreased during hypoglycaemia using myocardial contrast echo cardiography (MCE) in patients with type 1 diabetes mellitus (DM) and in healthy controls. Methods and Results: Twenty-eight volunteers with DM (patients with and without MVD) and 19 controls underwent hyperinsulinemic clamps with maintained sequential hyperinsulinemic euglycaemia (HE, plasma glucose 90 mg/dl, 5.0 mmollL) followed by hyperinsulinemic hypoglycaemia (HH, plasma glucose 50 mg/dl, 2.8 mmollL) for 60 minutes each. Low-power real-time MCE was performed with flash impulse imaging using low-dose dipyridamole stress, at baseline, and during HE and HH. In control subjects MBFR increased during HE by 0.57 units (22%) above baseline, (B coefficient 0.57, 95%CI 0.38, 0.75, p
Supervisor: Greaves, Kim ; Byrne, Christopher Sponsor: Not available
Qualification Name: Thesis (D.M.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: RC Internal medicine