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Title: Variation of cytomegalovirus glycoproteins in congenitally infected and immunocompromised populations
Author: Ellis, Julia Catherine
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 2006
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Human cytomegalovirus (HCMV) is an important opportunistic pathogen capable of causing severe disease in immunocompromised patients and congenitally infected infants. Human cytomegalovirus glycoproteins (gB, gN, gH, gL, gO and gM) are involved in attachment, penetration, viral entry, cell to cell spread and are also capable of inducing neutralising antibody responses. Polymorphisms within glycoprotein genes show focal areas of variability, which allow the identification of clustered genomic variants or genotypes. Little is known about functional differences between variants of glycoproteins H,N,L,0 and M or the occurrence of specific genotype configurations.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available