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Title: The development of catalytic phosphorus(V)-mediated reactions
Author: An, Jie
Awarding Body: University of Nottingham
Current Institution: University of Nottingham
Date of Award: 2013
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A redox-neutral catalysis strategy has been designed for the development of phosphorus-mediated substitution and elimination reactions. This new concept has been validated through the development of catalytic Appel halogenation reactions of alcohols, catalytic deoxydichlorination reaction of aldehydes and catalytic dehydration reaction of oximes. In these new catalytic reactions, oxalyl chloride is used as a consumable stoichiometric reagent to generate the chlorophosphonium salts responsible for halogenation or elimination from catalytic phosphine oxides. Therefore, phosphine oxides have been transformed from the stoichiometric waste products in traditional phosphorous-mediated reactions into organocatalysts. The substrate scope, limitations and mechanisms of the new catalytic reactions have been fully explored. Finally, a new cross coupling reaction berween triarylphospbines and aryl boronic acids has been developed for the synthesis of tetraarylphosphoruum salts.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available