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Title: Osteoporosis and factors that may influence bone mineral status in Shenyang, PR China
Author: Yan, Liya
Awarding Body: University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 1999
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The incidence and epidemiology of hip fracture in Shenyang, a large city in the north-east of PR China was investigated by collecting data from the admission and medical records from the 36 hospitals in Shenyang. Females and males in the age ranges 25-35 years and 65-75 years (48 to 50 in each group, 194 in total) were recruited for a cross-sectional comparison of bone mineral content (BMC), diet, anthropometry and bone metabolism. BMC was measured using dual energy X-ray absorptiometry at the lumbar spine and hip. Nutrient intakes of subjects were assessed by 5-day weighed food records. The biochemical markers of bone metabolism measured in plasma and urine were 25(OH)D, 1,25(OH)2D, parathyroid hormone, calcitonin, plasma and urinary calcium, phosphorus, total and bone specific alkaline phosphatase, osteocalcin, urinary sodium, potassium, deoxypridinoline and urinary titratable acidity. In addition, biochemical markers of bone metabolism of the young and old Chinese females in the cross-sectional study were compared with that of 32 British (19 old and 14 young) and 33 Gambian females (22 old and 11 young). The results demonstrate that the incidence of hip fracture in Shenyang was low, especially in women compared with more affluent countries; males had a higher overall incidence. The low incidence cannot be explained in terms of superior bone mineral status because old women and men both had low bone mineral status compared with young people, and bone mass was much better in old men than in old women. The pronounced low bone mass in old women was associated with increased bone turnover, but the reason for the low bone mineral status in old men is not clear. Poor vitamin D status, a low calcium and a high sodium intake appear to be the major risk factors for bone health in this population.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available