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Title: A study of psychotic symptoms in Alzheimer's disease : a cognitive and neuroimaging approach
Author: Venneri, Annalena
Awarding Body: University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 1999
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Delusions in AD have been poorly investigated and research focusing on identifying the neurobiological substrates of delusions in degenerative dementia has shown lack of consistent findings among studies. By using a cognitive and neuroimaging approach, we studied content specific delusions in AD with the aim to identify their neurological and cognitive correlates. Our data indicate that delusions in AD may be associated with areas of hypoperfusion in the right anterior hemisphere. Further, by selecting AD patients presenting delusions of similar content we have demonstrated that the locus of the brain dysfunction is crucial in determining the content of the delusion. Different delusions result from discrete foci of dysfunction within the right hemisphere. A substantial part of this project focused on a detailed study of a new form of delusion that we have termed autobiographical delusions. Findings showed that this form of delusion results from discrete dysfunction in the right frontal lobe. The patients with autobiographical delusions appear to share also a similar neuropsychological profile. When compared with patients not showing delusions, a difference in performance was detected in episodic memory and executive function tests.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available