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Title: The metabolic and immunological effects of the amino acid L-arginine on human tumours
Author: Park, K. G. M.
Awarding Body: University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 1993
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The aim of this thesis is to determine the relationship between feeding and the growth and metabolism of malignant tumours. In particular, the value of the dibasic amino acid L-arginine as a modifier of the complex host-tumour interaction. This work is presented in three sections. In section 1 the effects of nutrient intake on tumour protein synthesis are determined, as a sensitive indicator of tumour metabolism and growth. The previous developments and a recent study from our group measuring tumour protein synthesis, in vivo, as an assessment of tumour response to nutrients are discussed. The observed in vivo stimulation of tumour protein synthesis was further investigated in vitro to determine the effects of nutrients directly on tumour cells as opposed to tumour infiltrating lymphoreticular cells. These results showed that the tumour cells themselves reacted to feeding. Measurements of rates of protein synthesis, as a measure of tumour growth, are validated in section 2 by studying the growth of a human tumour cell line in vitro and as a xenograft in athymic nude mice. The remainder of the thesis investigates the use of the amino acid L-arginine as a nitrogen source in cancer patients. Section 2 concentrates on the effects of L-arginine on the growth of experimental tumour models and the metabolism of human breast cancers in vivo, using the techniques described in section 1. In both animal and human tumours, L-arginine resulted in a stimulation of tumour protein synthesis. Any overall effects of L-arginine on cancers, however, represent a balance between the effects on the host tissues and on the tumour, of particular importance is the effect on the host's anti-tumour defences and this is dealt with in section 3. It is concluded that L-arginine has stimulatory effects both on lymphoreticular cells and tumour cells.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available