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Title: A computer model of acute haemorrhage and resuscitation
Author: Menezes, Kevin Gerard
Awarding Body: University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 1998
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Acute haemorrhage cases are extremely difficult to analyse using randomised experimental studies and are well suited to computer modelling. The two main areas of current research are whether intravenous fluids should be administered to patients at the scene of an accident or not and what type of fluid should be given. A computer model was designed which analyses the fluid volume compartments within the human body. The relationship between the blood volume and blood pressure was examined, as was the transcipillary refill effect and the mechanics of the bleeding site. The model was then validated by comparing simulated predictions with previously published animal experiments for different sets of bleeding parameters. The agreement between published and predicted values of blood pressure and haematocrit was good (1.1% and 1.4 respectively). The model was then used to analyse the behaviour of intravenous fluids in trauma resuscitation. It was shown that crystalloid solutions do not follow the established pattern of leakage out of the intravascular system but that the half varies according to the degree of under resuscitation of the patient. The model was also used to determine the efficiency of three different accident site treatment protocols: no treatment, crystalloid infusion and colloid infusion. It was found that for shorter transport time (10-30 minutes) crystalloid infusion had to be at a high rate to be more efficient than no treatment. At high transport times (30-50 minutes) colloid infusion was more efficient that crystalloid and no treatment for medium infusion rates only.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available