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Title: The effect of copper and vitamin B12 deficiency on Babesia and Nippostrongylus infection in rats
Author: Kadir, M. A.
Awarding Body: University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 1981
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The development and pathogenicity of Babesia muratovi and Nippostrongylus brasiliensis were studied in Rowett Hooded rats fed on diets deficient or adequate in copper or in vitamin B12. The course of B. muratovi reached its peak in both adequate and deficient rats on day 6 after infection with inoculum 10⁷/20 g B.W. The parasitaemia was higher and the pathogenicity of Babesia was more severe in rats fed on the copper adequate diets than in copper deficient rats but there was no significant difference between rats fed on vitamin B12 deficient and vitamin B12 supplemented diets. The development of N. brasiliensis in rats was dependent on the dose of larvae inoculated. Higher worm and egg counts were obtained in rats infected with 3,000 larvae than in those infected with 1,500 larvae. The worm and egg counts were higher in simple copper deficient rats and gradually decreased with increasing dietary copper. The egg counts persisted for longer periods in copper deficient rats than in those fed higher levels of copper. The rats inoculated with 3,000 larvae had more severe symptoms. Although in thiomolybdate treated rats the worm and egg counts were lower in deficient than in adequate control rats, the pathogenicity of Nippostronqylus was more severe in deficient rats. The worm and egg counts were highest in vitamin B12 deficient male rats and decreased gradually with increasing dietary vitamin B12, but no such linear trend was seen in females. The development of N. brasiliensis was greater and its pathogenicity was more severe in rats fed diets deficient in copper and vitamin B12 than in those fed on diets adequate in these nutrients.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available