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Title: Dietary factors affecting selenium utilization by animals
Author: Abdel-Rahim, A. G.
Awarding Body: University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 1980
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The experiments in this thesis were carried out to investigate the effects of a range of possible antagonists of Se metabolism in the diets of sheep and rats. The results obtained can be summarised as follows: (i) Sulphur (0.04, 0.18 or 0.39;6) in the diets of sheep had the following effects on Se metabolism over a 29 week period. (a) The wool of sheep eating diets with 0.04% S contained significantly more Se than the wool from sheep eating the diets with 0.18 and 0.39% S. (b) An inverse relationship between dietary S concentration and Se concentration and GSH.Px activity in sheep livers was observed. (c) Sulphur treatment had no effect on plasma and whole blood GSH.Px activities and Se concentrations and at slaughter GSH.Px activities in kidney, spleen, heart and skeletal muscle were also unaffected. (ii) (a) in rats, increased dietary S (0.15, 0.3 and 0.5%) caused significant decreases in Se dependent GSH.Px activity in liver, spleen, heart, lungs, small intestine and skeletal muscle and Se concentrations of liver and hair. (b) The S treatment had no effects on growth and food intake of the rats. (iii) (a) High concentrations of Cu (200 and 500 mg/kg 1K) in the diets of rats had no effects on the retention of doses of 75Se03 . The tissue distribution of the absorbed 75Se was however altered by the Cu treatment. (b) The Cu treatments also decreased GSH.Px activity in liver, testis, kidney and whole blood of the rats. (iv) Dietary Mo (3 ors mg/kg) had no effect on Se metabolism or growth in sheep over a 31 week period during which they were Se depleted and then repleted with Se. (v) Dietary No (3-50 mg/kg), Cd (1-5 mg/kg), Mn (0.2-200 mg/kg) and Fe (25-500 mg/kg) had no effects on Se metabolism in the rat. Se metabolism being monitored by absorption of 75Se03 and GSH.Px activity in liver and whole blood. (vi) In conclusion it is unlikely that any of the following elements (S, No, Mn, Cd and Fe) at normal dietary concentrations will have a major effect on Se metabolism in animals. Cu however may be present in some diets at high enough concentrations to adversely effect Se metabolism.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available