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Title: Mechanisms of action of rosiglitazone in the protection of pancreatic beta cells from free fatty acid induced damage
Author: Landy, Caroline
Awarding Body: University of Brighton
Current Institution: University of Brighton
Date of Award: 2011
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A wealth of recent evidence implicates increasing obesity levels in the rising global epidemic of type 2 diabetes. At a cellular level, high fatty acid concentrations contribute to increasing p-cell dysfunction and eventual p-cell failure. We have shown that the thiazolidinedione (TZD) rosiglitazone has direct effects on pancreatic p-cell function. The aim of this study was to determine the cell signalling molecules mediating these effects, and to test the hypothesis that rosiglitazone can protect pancreatic p-cells from the detrimental effects of free fatty acids. Utilising the mouse p-cell line MIN6, MTT assays showed that at 5 mM glucose concentrations, addition of 0.4 mM palmitate for 72 hours resulted in a 60% loss of MIN6 cell viability (P
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: B000 Health Professions