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Title: Study of the effects of supraphysiological growth hormone administration in healthy young adults on metabolic variables and markers of sporting performance
Author: McHugh, Cathy
Awarding Body: University of Southampton
Current Institution: University of Southampton
Date of Award: 2012
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Growth hormone (GH) administration in individuals with GH deficiency improves physical performance by increased stroke volume and systemic vascular resistance, substrate availability, erythropoiesis, and altered body composition (increased lean body mass and reduced body fat). This study has evaluated the performance of a methodology developed by the GH-2000 research team to detect GH abuse in athletes. This is based on the measurement of IGF-I and Nterminal pro-peptide of collagen type III (P-III-NP), in non-Caucasian amateur athletes. This study has also evaluated the effects of 28 days of supraphysiological GH administration in GH replete health individuals on markers of performance including exercise capacity (V02 maximum), heart rate, substrate utilisation, body composition, and insulin resistance. The study has examined if any changes are associated with changes in serum adiponectin, NEFA or IGF-I concentrations. 36 healthy non-Caucasian amateur athletes completed a double blind randomised placebo controlled trial of 28 days of self-administered subcutaneous nightly GH injections (0.1 IU/kg/day or 0.2 IU/kg/day) or placebo.
Supervisor: Holt, Richard ; Sonksen, Peter H. Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available