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Title: The effect of topical negative pressure on microvascular blood flow in humans
Author: Ahmed, S.
Awarding Body: University of Southampton
Current Institution: University of Southampton
Date of Award: 2011
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Throughout history wound carers have used a variety of dressings to aid and promote wound healing. One of the most recent additions to the plethora of dressings used has been Topical Negative Pressure (TNP). This technique of wound management allows wounds that have been dressed with foam and sealed with an adhesive drape to be subjected to a variety of subatmospheric pressures (SAP) either in a continuous fashion or in a timed cycle. In a short space of time this technique has enjoyed widespread anecdotal success in the management of acute, chronic and difficult to heal wounds across a wide range of clinical specialities [1-18], which suggests that its application to wounds positively influences the wound healing process. If TNP does benefit the wound healing process, it is important to ask the question by what mean(s) it does so. There is however a paucity of studies investigating the mechanism(s) of action of TNP, particularly in human experimental situations. Although several investigators had evaluated the effect of TNP on blood flow in animal studies, at the beginning of this thesis, no studies in humans evaluating blood flow could be found. This thesis was therefore aimed at investigating the effect of TNP on microvascular blood flow in humans, and in particular three subatmospheric pressure (SAP) setting! cycles. Having investigated these SAP regimes an attempt was made at describing the macroscopic forces evident during TNP application (to intact skin and predominantly two-dimensional wounds), and the effect of these forces on tissues was visualised in a small number of healthy volunteers using Magnetic Resonance Imaging (MRI). It was envisaged that by describing the physical forces involved in TNP application a greater understanding of how TNP might effect changes in microvascular blood flow might become apparent.
Supervisor: Shearman, Clifford ; Mani, Raj Sponsor: Not available
Qualification Name: Thesis (D.M.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: RC Internal medicine