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Title: Temperature and cosolvent effects of polymer conformations in solution
Author: Jangher, Abdulhakim Ali
ISNI:       0000 0004 2752 0161
Awarding Body: Cardiff University
Current Institution: Cardiff University
Date of Award: 2011
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Formulation is a complex science. Many functional molecules require formulation to enhance their aqueous solubility or to promote and protect their function. Understanding the interaction between the formulation components is a necessary first step in that process. This project focuses predominantly on quantifying the interactions (synergistic and antagonistic) that arise when a triblock copolymer Pluronic (PI23) is mixed with the anionic surfactant sodium dodecyl sulfate (SDS), in the presence of the cosolvent, ethanol. The interaction between PI23 and SDS is synergistic, and leads to the formation of mixed micelles at low PI23 concentrations and liquid crystalline phases at high PI23 concentrations. Ethanol is shown to weaken that interaction, introducing antagonistic interactions at low PI23 concentrations. Moreover, we also study the physicochemical characteristics of some new biocompatible responsive polymers with potential biomedical applications. Here, the "formulation" is inherently built into the structure of the polymer-protein construct. These constructs possess a thermo-responsive character, and pulsed-gradient spin- echo NMR (PGSE-NMR) and small-angle neutron scattering (SANS) have been used to examine the solution conformation of these polymers as a function of temperature.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available