Use this URL to cite or link to this record in EThOS:
Title: Gamma-synucleinopathy in mice (and humans?)
Author: Peters, Owen
ISNI:       0000 0004 2751 4968
Awarding Body: Cardiff University
Current Institution: Cardiff University
Date of Award: 2011
Availability of Full Text:
Access from EThOS:
Access from Institution:
As a result of these findings we assessed the distribution of gamma-synuclein in spinal cord samples of sporadic and familial amyotrophic lateral sclerosis. Though not a component of any typical ALS-associated inclusion bodies, we identified gamma-synuclein positive structures in the corticospinal tracts of several of the cases examined. All these cases shared a common pronounced loss of upper motor neurons and demyelination of the spinal cord portion of their axons. We thus propose that the unidentified gamma-synuclein positive structures represent a novel corticospinal tract inclusion structure or alternatively present a novel marker of a subtype of amyotrophic lateral sclerosis with pronounced upper motor neuron involvement.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available