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Title: Investigating the mechanistic basis of telomeric fusions
Author: Heppel, Nicole H.
ISNI:       0000 0004 2751 3762
Awarding Body: Cardiff University
Current Institution: Cardiff University
Date of Award: 2011
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Furthermore, NBS1 deficiency results in a paucity of sporadic telomere deletion events which is consistent with the hypothesis that NBS1 is involved in the resolution of Holiday junctions within T-loops creating telomeric deletion events. In contrast, DNA Ligase IV deficiency and PARP1 inhibition caused distinct short telomere length distributions. Both these phenotypes might be related to problems with telomere replication.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available