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Title: The effects of surface modification on the osseointegration of titanium dental implants
Author: Colombo, John Samuel Lawrence
ISNI:       0000 0004 2751 1839
Awarding Body: Cardiff University
Current Institution: Cardiff University
Date of Award: 2010
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In vitro , BMSCs cultured on M appeared more rounded, while they were more elongated on GB or TCP. BMSCs attached preferentially to M. The matrix formed appeared as a thin layer covering M, while matrix was thicker on the GB and TCP surfaces, infilling topographical features. Surface modification appeared to have little effect on the osteogenic activity of BMSCs. However, titanium was found to suppress differentiation down the adipogenic pathway and expression of inflammatory cytokines compared to plastic. Surface modification appeared to have little effect on osteoblasts activity or osseointegration, although roughened surfaces may provide better mechanical interlocking with bone. In vivo, no differences in the progression of osseointegration around any of the modified surfaces were observed. In DM, osteoblasts activity was altered and bone healing was delayed. There is therefore clearly scope to investigate surface modifications such as biomimetic coatings for use in compromised clinical situations.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available