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Title: Effect of cellular aging on fibroblastic phenotype and regulation by hyaluronan
Author: Simpson, Russell Michael Lloyd
ISNI:       0000 0004 2751 0318
Awarding Body: Cardiff University
Current Institution: Cardiff University
Date of Award: 2010
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Collectively, the data demonstrated that HA can serve as a signal integrator by facilitating TGF-beta11-mediated CD44-EGF-R-ERK interactions and ultimately regulate fibroblast phenotype. I propose a model to explain this novel mechanism and the functional consequence of age-dependent dysregulation. This mechanism may have direct implications for modifying the wound healing response, particularly for developing therapeutic strategies to improve healing in the elderly.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available