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Title: Proteoglycans in the corneal stroma and their role in development and pathology
Author: Palka, Barbara Paulina
ISNI:       0000 0004 2749 9833
Awarding Body: Cardiff University
Current Institution: Cardiff University
Date of Award: 2010
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Transmission electron microscopy of a human cornea with excess chondroitin sulphate/dermatan sulphate glycosaminoglycan showed that changes in proteoglycan structure, content and sulphation lead to the formation of abnormally large collagen fibrils. The lack of sulphation of keratin sulphate in MCD also led to abnormally large fibrils, which are present in the deep stromal layers. These findings suggest overlapping roles of the two proteoglycan populations in the corneal stroma with possible feedback mechanisms, too. Taken together, the findings of this thesis indicate the central role played by proteoglycan-collagen interactions in the development and maintenance of properly formed corneal stroma.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available