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Title: The genetics and epidemiology of myopia in the ALSPAC cohort
Author: McMahon, George
ISNI:       0000 0004 2749 9825
Awarding Body: Cardiff University
Current Institution: Cardiff University
Date of Award: 2010
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An aim of this thesis is to map a genetic factor that is related to myopia progression. A genome-wide association study of myopia, refractive error and two ocular determinants of refractive error, axial length and corneal curvature was undertaken. A number of genetic locations were identified and extra genotyping and replication in an independent cohort is underway. A further aim of this thesis is investigation of an environmental risk factor of myopia. Epidemiological analyses of two myopia risk factors were undertaken; one in the ALSPAC cohort, another in a cohort from Northern England. In both cases, a relationship with myopia was identified and a plausible mechanism for the relationship is discussed.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available