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Title: Molecular dissection of neurofibromatosis type 1 tumorigenesis
Author: Majounie, Elisa
ISNI:       0000 0004 2747 5380
Awarding Body: Cardiff University
Current Institution: Cardiff University
Date of Award: 2009
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The present study investigated the possible involvement of nine candidate genes in NF1 tumours by assessing loss of heterozygosity, promoter hypermethylation, and expression in NF1-related tumours. The CDKN2A/p16INK4a , RB1, TP53 and MGMT genes have previously been found to be altered in NF1 tumours, and this was confirmed in this study. However, new candidate genes were also found to be involved in NF1 MPNSTs and rare malignancies (RARB, MLH1 and RASSF1A).
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QH426 Genetics ; RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry