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Title: Alpha-functionalisation of carbonyl compounds
Author: Killeen, Niall M.
ISNI:       0000 0004 2751 1695
Awarding Body: Cardiff University
Current Institution: Cardiff University
Date of Award: 2007
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Chapter 1: Intrinsic to the methodology developed within this thesis is the exploitation of a polyheteroatom 3,3-sigmatropic rearrangement. This chapter explores the chemistry of a selection of these rearrangements in order to highlight their utility in the creation of new carbon-carbon and carbon-heteroatom bonds. Chapter 2: In this chapter the most recent advances in the alpha-functionalisation of carbonyl compounds are discussed. This review focuses mainly on organocatalyzed methodologies as these represent the forefront of current research in the field. Chapter 3: In chapter 3 the principle underlying our methodology is further described along with our results for the alpha-oxybenzoylation of cyclic, heterocyclic and acyclic ketones. Our findings for the alpha-oxybenzoylation of acetals is also described. Chapter 4: Elaboration of our family of reagents to introduce alpha-oxycarbonate and carbamate functionalities is next described with our results for a variety of reactions with cyclic and acyclic ketones. Chapter 5: Continuing expansion of our reagent family is described in chapter 5. Within this chapter our results for the alpha-oxytosylation of cyclic, acyclic and di-carbonyl compounds are presented. Chapter 6: Chapter 6 describes our attempts at synthesising a thio analogue of our reagent for the creation of a C-S bond.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available