Use this URL to cite or link to this record in EThOS:
Title: Studies towards the synthesis of the batzelladine alkaloids
Author: Wordinghan, Stuart V.
ISNI:       0000 0004 2748 5319
Awarding Body: Cardiff University
Current Institution: Cardiff University
Date of Award: 2006
Availability of Full Text:
Access from EThOS:
Access from Institution:
This thesis describes studies into the synthesis of the batzelladine alkaloids including a detailed study into the synthesis of alkylidenepyrrolidines. Chapter 1 is a brief introduction to the batzelladine alkaloids highlighting all significant work carried out since their isolation in the mid 1990's. Chapter 2 looks at the viability of Lewis acid promoted Friedel-Crafts reactions for the formation of quinolones, and the usefulness of this reaction to the synthesis of batzelladine alkaloids. Chapter 3 includes a detailed methodology study into the formation of alkylidenepyrrolidines, and the reasons why a new synthesis is required. Chapter 4 investigates the Kishi three-component coupling reaction, including a mechanistic study and a synthetic study. Chapter 5 describes our work into the synthesis of batzelladine C and incorporates the work carried out and detailed in Chapters 2 and 3.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available