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Title: Evaluation of a new hypoglycaemia symptom measure: the hypoglycaemia symptom rating questionnaire (HypoSRQ)
Author: Taylor, Michelle Dawn
ISNI:       0000 0004 2749 8590
Awarding Body: Royal Holloway, University of London
Current Institution: Royal Holloway, University of London
Date of Award: 2012
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There are no well-validated questionnaires designed specifically to assess hypoglycaemia symptoms among patients with diabetes. This research aimed to provide preliminary validation of the Hypoglycaemia Symptom Rating Questionnaire (HypoSRQ), which was designed to provide a comprehensive assessment of hypoglycaemia symptoms. A cross-sectional design was used with a longitudinal component for patients who volunteered to use continuous glucose monitoring (CGM). Participants (N = 103) were invited to complete the HypoSRQ (recent-weeks) and psychological questionnaires including diabetes outcome measures. Thirty patients used CGM for 6 days and completed the HypoSRQ (24-hour version) at the end of each day for seven days, at the end of each week (7 -day version) and at the end of four weeks (recent-weeks version). Five patients used CGM for 28 days to allow in depth within-person analyses of the relationships between HypoSRQ scores and CGM-measured hypoglycaemia. The HypoSRQ had a one-factor structure and excellent internal consistency reliability. There was high correspondence in recall of hypoglycaemia symptoms, bother ratings, and the number of hypoglycaemic episodes reported using the daily versions of the HypoSRQ and the weekly version of the HypoSRQ, and using the weekly versions of the HypoSRQ and the recent-weeks version. In multiple regression analyses, age, depression and worry about hypoglycaemia made an independent contribution to hypoglycaemia symptom reporting. Higher HypoSRQ scores were also moderately correlated with poorer quality of life and well-being. The •• 5 ••••......... ---------------------------- number of hypoglycaemic episodes reported using the HypoSRQ was significantly correlated with CGM-measured hypoglycaemia in between- person and within-person analyses. The relationship between symptom reporting and CGM-detected hypoglycaemia was not straightforward and appeared to be influenced, in part, by psychological factors. The HypoSRQ is recommended as a clinical and research tool to measure hypoglycaemia symptoms among people with type 1 and insulin-treated type 2 diabetes. Potential clinical applications and suggestions for future research are discussed.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available