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Title: Secondary metabolites from Xylariaceous fungi : the isolation and structure elucidation of secondary metabolites from Xylariaceous fungi by chemical and spectroscopic methods
Author: Alhaidari, Rwaida Adel
ISNI:       0000 0004 2747 7175
Awarding Body: University of Bradford
Current Institution: University of Bradford
Date of Award: 2012
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This thesis describes the isolation and structure elucidation of secondary metabolites formed in static culture from a number of endophytic Xylariaceous fungi. Four Xylaria endophytes isolated from a palm tree in Thailand were surface cultured on an aqueous malt extract-glucose medium. They all produced cytochalasin D, coriloxin, (S)-mellein and (3R,4R)-4-hydroxymellein as the main secondary metabolites suggesting that the four endophytes could be the same species. The endophytic fungus A116 produced cytochalasin D as the main secondary metabolite. Another non-endophytic fungus B315, produced cytochalasin D, (R)-mellein, a mixture of two isomers of 4-hydroxymellein and phloroglucinol. X.62, an endophytic fungus, produced 19,20-epoxycytochalasin C from the mycelium as the main secondary metabolite. The fungus Engleromyces sinensis produced engleromycin acetate as the main secondary metabolite. Fungus X. polymorpha produced (3E)-4-(3'-acetyl-2',6'-dihydroxy-5'-methylphenyl)-2-methoxybut-3-enoic acid.
Supervisor: Maitland, Derek J. Sponsor: Ministry of Higher Education, Kingdom of Saudi Arabia
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Endophytes ; Xylaria ; Fungi ; Secondary metabolites ; NMR ; Structure elucidation ; Xylariaceous fungi