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Title: Inducible soluble VEGF receptor overexpression in Glomeruli: implication for the physiological role of VEGF in the kidney (Generation of animal model and preliminary data)
Author: Dei Cas, Alessandra
ISNI:       0000 0004 2745 1768
Awarding Body: University of London
Current Institution: King's College London (University of London)
Date of Award: 2007
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VEGF plays an important role during nephrogenesis and glomeulogenesis. In most adult tissues VEGF is downregulated but it remains constitutively expressed in capillaries with fenestrated endothelium such as in the glomeruli. In the kidney, VEGF is expressed and secreted by podocytes and its receptors are expressed on endothelial cells. The role of constitutive VEGF expression in the adult glomerulus is only partially understood. The aim of this study was to generate an in vivo system whereby VEGF action could be inhibited specifically in the kidney and selectively in the adult fully developed glomeruli. Our working hypothesis was that VEGF could be responsible for the maintenance of endothelial fenestration in glomerular capillaries and possibly playing a role in the filtration or water and solutes. Using a transgenic approach, we over-expressed, with an inducible system, specifically in the glomeruli the soluble truncated VEGF receptor (sFlt-I). By over-expressing sFlt-l in our system, we obtained some preliminary results that suggest a critical role ofVEGF in the functionality of the glomerular filtration barrier.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available