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Title: The role of CRH in placental biology : studies employing a choriocarcinoma cell line
Author: Delidaki, Maria
ISNI:       0000 0004 2748 3612
Awarding Body: University of Warwick
Current Institution: University of Warwick
Date of Award: 2011
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The hypothalamic component of HPA–axis CRH is also produced by the placenta and it has been postulated to control a “placental clock” during pregnancy which determines the onset of parturition. However, the role of CRH in early trophoblast biology is currently unknown. In this thesis we investigated the role of CRH/CRH receptor in early placentation using the fusigenic choriocarcinoma cell line BeWo. These cells expressed functional CRH-R coupled to MAPK signalling cascades. In this cellular model, CRH was shown to promote survival and to induce cell proliferation, however in the presence of differentiation-inducing signals (such as forskolin) CRH further augmented up-regulation of fusogenic gene expression and hCG secretion induced by forskolin. Therefore, placental CRH appears to influence placenta biology. Finally, it was shown for the first time that CRH actions were sensitive to TLR4 activation raising the possibility that the innate immune system is an important regulator of placental CRH biological actions.
Supervisor: Not available Sponsor: University of Warwick
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QP Physiology