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Title: N-acetylneuraminic acid lyase : deciphering the mechanistic and structural consequences of non-natural amino acid incorporation
Author: Timms, Nicole
ISNI:       0000 0004 2748 2388
Awarding Body: University of Leeds
Current Institution: University of Leeds
Date of Award: 2011
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In Nature, the protein backbone is assembled from a set of 20 proteogenic amino acids. The vast diversity of the proteome is due, only in part, to the range of protein encoding genes. Additional functionalities and complexities are introduced by post-translational modification, and/or the recruitment of eo-factors, prosthetic groups and metal ions. Taking inspiration from the range of protein modifications seen in Nature, the chemical incorporation of non-natural amino acids into an enzyme's active site, for example, may enable novel mechanisms of catalysis or alter substrate specificity.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available