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Title: Transition metal catalysed C-C bond formation via C-H functionalisation
Author: Truscott, Fiona Rosemary
ISNI:       0000 0004 2745 1215
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 2012
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The functionalisation of C-H bonds has been widely studied in organic synthesis. This work presents the results of investigation into two areas of current research, copper-catalysed aromatic C-H functionalisation and rhodium-catalysed hydroacylation. Chapter 1 presents the development of palladium- and copper-catalysed aromatic C-H functionalisation with particular attention paid to regiocontrol. Chapter 2 describes the development of copper-catalysed cross-coupling of perfluorinated arenes and alkenyl halides along with efforts to expand this methodology to a more general reaction. In Chapter 3 the development of chelation-controlled rhodium-catalysed hydroacylation is discussed. Chapter 4 outlines the utilisation of amino acid derived N-methylthiomethyl aldehydes in rhodium-catalysed hydroacylation methodology.
Supervisor: Willis, Michael C. Sponsor: EPSRC ; AstraZeneca
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Chemistry & allied sciences ; Catalysis ; Organic chemistry ; Organic synthesis ; Organometallic Chemistry ; Synthetic organic chemistry ; copper ; rhodium ; cross coupling ; hydroacylation ; C-C bond formation ; C-H functionalisation