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Title: A study into calmodulin dependent regulation of 'Schizosaccharomyces pombe' myosin I
Author: Alexander, Christopher J.
ISNI:       0000 0004 2747 5815
Awarding Body: University of Kent
Current Institution: University of Kent
Date of Award: 2012
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Myosins are a large superfamily of actin binding ATPase motor proteins involved in a variety of different cellular functions. These conserved motors are not only regulated by post-translatlonal modifications, such as phosphorylation, but also by interactions with other proteins including their light chains. These light chains modulate the structure of the myosin heavy chain, often by stiffening the neck region of the myosin to provide a rigid lever arm. In all non-conventional myosins studied to date, calmodulin, a highly conserved calcium regulated globular protein, acts as the myosin light chain, associating with IQ motifs within the heavy chain neck region in a calcium dependent manner.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available