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Title: Modulation of myocardium repair after ischemic injury : role of macrophages
Author: Mohammed , Salman Afroze Azmi
ISNI:       0000 0004 2745 5945
Awarding Body: Open University
Current Institution: Open University
Date of Award: 2012
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Macrophages are primary responders that are involved in regulation of left ventricular remodeling post myocardial infarct (MI) at various levels. Macrophage role post ischemia can be best studied by eliminating or blocking their population and also by increasing their numbers, and determining the outcome. Four different approaches to modulate macrophage number or activity have been used: a) human diphtheria toxin receptor (hDTR) transgenic mice; b) injection with clodronate liposomes (CL) in C57 mice; c) pharmacologic blockade of TLR4 which is expressed also in macrophages; d) selection of Ml or inflammatory macrophages, by adoptive transfer of NF-kB P50-/- bone marrow (BM).
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available