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Title: Light triggered biomaterials
Author: McGoldrick, Niamh
ISNI:       0000 0004 2742 062X
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2012
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Implantable devices such as urethral catheters are the most commonly used urological devices. The most common problem affecting these devices is infection, leading to significant morbidity and eventual mortality. The challenge is to alleviate the long-term issue of device related infection. This study involved the development of light-responsive biomaterials, which demonstrated the controlled release of model therapeutic agents from within the polymer matrix, when irradiated with a specific wavelength of light. The use of light as a trigger for the release of a therapeutic agent from a polymeric matrix is attractive, as wavelength, intensity, site and duration of application of light can be coupled to release of the therapeutic agent. The pphotolabile ester of3,5-dimethoxybenzoin with a model acidic drug (ibuprofen) attached was synthesised and loaded into the polymer scaffold, which comprised of2-(hydroxyethyl) methacrylate crosslinked with ethyleneglycol dimethacrylate, once irradiated, the porous hydrogel allowed the diffusion of the model drug from the polymer matrix once liberated, and the retention of the photolytic by-product within the polymer structure. A second 3,5-dimethoxybenzoin ester was synthesised with ciprofloxacin attached, achieving controlled release of an antimicrobial in situ, thus preventing bacterial adherence and subsequent biofilm formation. The idea of chromatic orthogonality was explored and the 3,5-dimethoxybenzoin and nitrobenzyl derivatives were synthesised and utilised due to their differential reactivities at specific wavelengths, allowing multi-drug release, stimulated using monochromic light of different wavelengths. Light triggered transdermal drug delivery was examined,. novel pHEMA microneedles with the light reactive conjugate incorporated into the matrix were successfully synthesised. Drug release studies demonstrated the ability of the pHEMA microneedles to penetrate the synthetic skin and deliver the model drug ibuprofen. Modification of the surface ofa silicone biomaterial to allow the incorporation of two different porphyrins Meso- Tetraphenylporphyrin and Protoporphyrin IX was carried out, in order to develop an anti-adherent surface, preventing attachment of microorganisms and subsequent biofilm formation. An anti-infective surface has been developed which is successful at preventing bacterial colonisation of Gram-positive microorganism. The concept of light-triggered drug release of a model therapeutic agent from a hydrogel biomaterial has been demonstrated, it offers an exciting new prospect within drug delivery.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available