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Title: Fruit, vegetables and dietary patterns in relation to cardiovascular and eye health
Author: McEvoy, Claire Teresa
ISNI:       0000 0004 2742 0558
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2012
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This thesis employed a number of methods to examine the relationship between fruit and vegetable (FV) intake, dietary patterns and vascular health. A major aim was to examine the secondary end-point measurements within Fruit, vegetable and Insulin Resistance STudy (FIRST). Overweight participants at high cardiovascular disease (CVD) risk were randomised to 2,4 or 7 portions FV for 12 weeks and CVD risk factors were measured pre- and post- intervention. Eighty nine participants completed the study and despite evidence of good compliance, increased FV intake did not have a significant effect on blood pressure, lipid levels or C-reactive protein. Quantification of the retinal vessel caliber (RVC) is an emerging method to examine the microvasculature in vivo. Increasing FV intake had no significant effect on measured RVC in a subsample of FIRST participants. A second aim was to explore associations between dietary patterns and RVC in a cross-sectional study involving an elderly population (n= 288). Three major dietary patterns were identified using principle component analysis (PCA), however no significant associations were observed between dietary patterns and measured RVC. A third aim was to conduct a review of observational studies investigating the association between a posteriori-derived dietary patterns and risk of type 2 diabetes (T2DM). A meta- analysis was performed of prospective studies that investigated the association between PCA-derived dietary patterns and T2DM risk in approximately 271,702 participants and 16,020 incident cases of T2DM. The results demonstrated a significant reduction in T2DM risk for individuals in the highest category of healthy dietary pattern compared with those in the lowest category (OR 0.86; 95% CI:0.80, 0.91; P < 0.00001). Furthermore, a significant increase in risk ofT2DM was observed for those in the highest unhealthy dietary pattern category when compared with those in the lowest category (OR 1.42; 95% Cl: 1.32, 1.53, P < 0.0001).
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available