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Title: The role of ODV structural proteins in baculovirus replication
Author: Chambers, Adam C.
ISNI:       0000 0004 2744 0284
Awarding Body: Oxford Brookes University
Current Institution: Oxford Brookes University
Date of Award: 2012
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Baculoviruses are arthropod-specific viruses with a circular, double-stranded DNA genome (80-180 kb). Two structural forms are produced during virus replication, comprising budded virus (BV) and occlusion-derived virus (ODV). The BV is produced from 12 hours post infection (hpi) and spreads the infection from tissue to tissue within the host. The ODV is formed 20 hpi and enveloped within occlusion bodies (OBs). The aim of this project was to elucidate the mechanisms involved in ODV production by deleting putative genes involved in ODV, but not BV production. A secondary aim of the project was to determine whether removing these genes improved the quantity/quality of recombinant proteins produced by baculovirus expression vectors.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available