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Title: Study of a polymorphic human trophoblast antigen bound to maternal antibody
Author: Jalali, Gholam Reza
ISNI:       0000 0004 2743 2911
Awarding Body: Imperial College London
Current Institution: Imperial College London
Date of Award: 1998
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IgG is found bound to the maternal surface of human placental microvesicles, and can be eluted between pH 6 and pH3. Some is bound to Fc receptors, but that which only elutes below pH 4.0 appears to be bound to a syncytiotrophoblast antigen. When IgG antibody was eluted at pH3 and reacted with its own acidified vesicles or those from other placentae, the alloantibody always bound to the preparation from which it was obtained, but only to about 16.7% of preparations from other placentae. Similarly it did not bind to the native vesicle unless IgG was first removed using acid. The antigen thus appeared to be polymorphic, and further investigation showed that it was an 80 kDa surface protein of the trophoblast. A similar polymorphic protein in term equine placentae was also found to have bound IgG antibody. It showed similar cross reactivity, with other equine, but not with human, microvesicles.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available