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Title: The role of pax genes in vertebrate segmentation
Author: Wright, David
ISNI:       0000 0004 2741 2873
Awarding Body: University of Dundee
Current Institution: University of Dundee
Date of Award: 2010
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Pax genes are involved in a range of processes in the developing embryo. Pax3 and Pax7 in particular are associated with the paraxial mesoderm, especially the development of the myogenic lineage. However, recent studies have suggested that Pax3 and Pax7 may have earlier, morphogenetic roles in the segementation of the paraxial mesoderm. Here we examine the expression of Pax3 and Pax7 in the chicken presomitic mesoderm, and investigate their function using an in ovo electroporation transfection technique. We find that Pax3/7 drives precocious differentiation of PSM towards the myogenic lineage, as well as inducing a range of morphological changes in PSM tissue. These changes include alterations in the cytoskeleton, cell adhesion, and extracellular matrix formation.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available