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Title: The economical production of bryostatin & Et-743 with biological activity
Author: Abadi, Giso
ISNI:       0000 0004 2745 1039
Awarding Body: University of Sunderland
Current Institution: University of Sunderland
Date of Award: 2009
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Within the past fifty years, drugs from the sea have become an increasing industry for the identification and isolation of new medicinal agents. Bryozoa, sea squirts and corals are examples of many organisms that have been collected and tested for medicinal activity. Clinical testing’s of drugs such as bryostatin 1 and Et-743 have shown much success against various cancers such as kidney, prostate, and leukemia, etc. However, there are many problems affecting the economical availability of such drugs such as: 1. the potential endangerment of marine organisms due to massive quantities required for clinical use; 2. seasonal availability of the organisms and 3. numerous synthetic steps resulting in low percent yields to name a few. Detailed analyses conducted of the environment of these marine organisms resulted in the composition of chemicals that were used as an artificial property to mimic the host organisms and their environments, resulting in the cultivation of the bacteria suggestively responsible for the production of these active compounds. Other experiments conducted, involved the esterification of bryostatin 1 under various conditions, in order to show that such compounds produced, are more environmentally obtainable as opposed to being specie dependent. Computational studies binding Fe3+ to different marine natural products was also conducted in order to determine any siderophore properties that each may have. From this study cell line tests were conducted in order to determine the efficacy of a bryostatin-Fe3+ complex in comparison to bryostatin 1. Preliminary results from all the artificial media used to isolate and produce the bryostatins and Et-743 showed prominence; however, results were inconclusive due low detection values and marginal errors.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Pharmacy and Pharmacology