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Title: Organic and metal organic cationic DNA intercalators based on DPPZ analogues
Author: Derrat, Hanan S.
ISNI:       0000 0004 2742 6554
Awarding Body: University of Sheffield
Current Institution: University of Sheffield
Date of Award: 2012
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New metal complex derivatives of tppz containing cationic "diquat" sites have been synthesized and characterized. Their interaction with DNA has also been explored .. Water-soluble organic cationic derivatives of the dppz ligand with a variety of functional groups and number of aromatic rings in the phenazine region have also been synthesised and characterized. These systems were synthesized with the aim of modulating the energy of the internal charge transfer excited state of the parent cation. The interactions of the new organic diquaterary salts of dppz with ON A have been studied. Metal complexes containing dppz ligands that are the free base analogues of the cationic systems have also been synthesized and their interaction with DNA has also been investigated.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available